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Center for Astrophysics Research and Technologies Seminar Series Information


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Extracting Hidden Information from your Fluorescence Microscope

Thursday March 5, 2020
2:00 pm

 Presenter:  Mikael P. Backlund, Harvard University
 Series:  Biophysics Seminar
 Abstract:  Fluorescence microscopy is a workhorse technique in both biological and abiological imaging and sensing. A fluorescence photon can carry information encoded in its position, momentum, polarization, phase, spectrum, and timing, but off-the-shelf microscopes are poor conduits of most of this information. As a consequence, efficiently extracting information from the specimen often requires redesign of the microscopy experiment in a way that leverages some additional physical know-how.

Here I will focus on two studies that demonstrate this concept. First I will discuss the fundamental limits associated with determining the three-dimensional position of a fluorescent emitter, with insights provided by quantum parameter estimation theory. Second, I will show how nitrogen-vacancy (NV) centers in diamond can be used to convey three-dimensional magnetic field information from the sample to the microscope.

These and related approaches push the limits of what can be measured with a fluorescence microscope, offering exciting new possibilities for the molecular sciences.
 Host:  Keith Lidke
 Location:  1100, PAIS

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