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Early in vivo cancer detection by superparamagnetic relaxometry

Thursday February 23, 2017
11:00 am

 Presenter:  Dr. Todor Karaulanov of Imagion Biosystems, Inc.
 Series:  OSE Seminars
 Abstract:  Clinically, the early cancer detection is directly linked to improved clinical outcomes and overall survival. Unfortunately, existing clinical methods for early detection lack sensitivity and/or specificity. The method of superparamagnetic relaxometry (SPMR) offers a rare opportunity in early diagnostics. The Imagion Biosystems' SPMR platform combines targeted delivery of superparamagnetic nanoparticles to tumor cells and their detection with very sensitive magnetic sensors - atomic magnetometers (AM) and/or superconductive quantum interference devices (SQUIDs). The advantage of SPMR over other methods for detection of magnetic particles (e.g., magnetic particle imaging) is in the differentiation of the particles bound to cancer cells versus those in circulation. Thus, only the tumor cells are made "visible". This unique quality is possible due to the clear distinction of the relaxation times of bound particles (Neel relaxation) and not bound particles (Brownian relaxation). In vitro and in vivo preclinical data will be presented. Clinical applications will be discussed too.
 Location:  Room 190, Physics & Astronomy

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