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Center for Astrophysics Research and Technologies Seminar Series Information

 

Events Calendar

Fluorescence Nanoscopy

Friday October 31, 2014
4:00 pm


 Presenter:  Keith Lidke
Department of Physics and Astronomy, UNM
 Series:  Physics and Astronomy Colloquium
 Abstract:  Due to the near transparency of biological cells, optical imaging is well suited for studying live or intact cells. Tagging cellular components with fluorophores dramatically extends these capabilities by providing molecular specificity and improved contrast. However, the light microscope is limited by diffraction to ~ 300 nm, whereas many important events for cell function and signaling involve structures or interactions at the ~ 10 nm scale. The 2014 Nobel Prize in Chemistry was awarded to three researchers “for the development of super-resolved fluorescence microscopy” that push or circumvent the diffraction limit, enabling the study these structures and events. I’ll discuss the concepts behind these strategies and give a brief history of their development over the last two decades.

This area of research, often now called ‘Fluorescence Nanoscopy,’ has virtually exploded over the past decade and is still rapidly growing - both in its use for studying biological systems and its further developments that push speed, resolution, quantification, and the number of different types of structures that can be simultaneously measured. I’ll discuss our recent and ongoing work in this area including developments in 3D super-resolution imaging as well as high-speed hyperspectral imaging for observing and measuring protein-protein interactions on cell membranes.
 Host:  James Thomas
 Location:  Room 125, Dane Smith Hall
 

Refreshments will be available before the colloquium, at 03:45 pm, in in the lobby of Dane Smith Hall.

Disability Notice Individuals with disabilities who need an auxiliary aid or service to attend or participate in P&A events should contact Sandra Ortiz (phone: 505-277-5900, email: sportiz@unm.edu) well in advance to ensure your needs are accommodated. Event handouts can be provided in alternative accessible formats upon request. Please contact Ms. Ortiz if you need written information in an alternative format.